Ludwig Tumor Atlas Ludwig Cancer Research

Data

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TMA of 16 Breast Cancer Samples and Normal Tissue (BC03)

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Multiplexed 3D atlas of state transitions and immune interactions in colorectal cancer (CRC01 Z-stack)

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Graphical Abstract - Multiplexed 3D atlas of state transitions and immune interactions in colorectal cancer

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Pathological annotations - Multiplexed 3D atlas of state transitions and immune interactions in colorectal cancer - CRC01

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Melanoma in-situ with 3D imaging

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P138007

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P137974

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P137941

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P137905

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P137757

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P137753

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P137591

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P136690

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P133537

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P132666

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P132630

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P132115

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BRCA1-Associated Triple Negative Breast Cancer

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Combination Therapy in Ovarian Cancer

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    Genetically engineered mouse model of lung adenocarcinoma

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    Lung Adenocarcinoma Metastasis to Lymph Node

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    Primary Squamous Cell Carcinoma of the Lung

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    crc-case-1-ffpe-cycif-pilot

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    Patient 1 - Melanoma with precursor fields

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    Patient 2 - Melanoma in situ, invasive melanoma, precursor field and inflammatory regression

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    Patient 2 - Inflammatory regression and brisk TILs

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    Patient 2 - Melanoma in situ, invasive and polypoid melanoma

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    MEL13-2-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL13-2-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL13-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL13-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL12-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL12-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL11-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL11-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL10-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL10-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    Deep Exploration of a Primary Melanoma (MEL 1 Full Story)

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    Introduction to the MEL Atlas (MEL 1 Abstract)

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    MEL09-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL09-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL08-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL08-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL07-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL07-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL06-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL06-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL05-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL05-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL04-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL04-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL03-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL03-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL02-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL02-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL01-3-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL01-3-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL01-2-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL01-2-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL01-1-6 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL01-1-5 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL01-1-4 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL01-1-3 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL01-1-1 - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    MEL01-1-0 - H&E - overview - Nirmal, Maliga, Vallius, Sorger et al., 2021

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    Z147

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    Ovarian Cancer with Annotation - LSP15343

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    Ovarian Cancer with Annotation - LSP15327

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    MITI - LSP15343

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    LSP16696

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    LSP16697

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    LSP16698

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    LSP16699

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    LSP16814

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    CK1 (BRCA wildtype)

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    CK2 (BRCA wildtype)

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    CK3_R (BRCA wildtype)

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    CK4_P (BRCA wildtype)

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    CK4_R (BRCA wildtype)

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    CK5 (BRCA wildtype)

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    CK6 (BRCA wildtype)

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    CK7 (BRCA wildtype)

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    CK8 (BRCA wildtype)

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    CK9 (BRCA wildtype)

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    CK10 (BRCA wildtype)

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    CK11 (BRCA wildtype)

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    CK12 (BRCA wildtype)

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    CK13 (BRCA wildtype)

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    CK14 (BRCA wildtype)

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    CK15 (BRCA wildtype)

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    CK16 (BRCA wildtype)

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    CK17_M (BRCA wildtype)

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    CK18_P (BRCA wildtype)

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    CK19_BCC (BRCA wildtype)

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    CK19_BCC2 (BRCA wildtype)

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    CK20 (BRCA wildtype)

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    CK21 (BRCA wildtype)

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    CK22 (BRCA wildtype)

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    CK23 (BRCA wildtype)

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    CK24 (BRCA wildtype)

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    CK25_R (BRCA wildtype)

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    CK26 (BRCA wildtype)

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    W2BC_3 (BRCA wildtype)

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    W8B_4 (BRCA wildtype)

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    K1 (BRCA mutant)

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    K2 (BRCA mutant)

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    K3 (BRCA mutant)

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    K4 (BRCA mutant)

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    K5 (BRCA mutant)

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    K6 (BRCA mutant)

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    K7 (BRCA mutant)

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    K8 (BRCA mutant)

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    K9 (BRCA mutant)

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    K10 (BRCA mutant)

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    K11 (BRCA mutant)

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    K12 (BRCA mutant)

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    K13 (BRCA mutant)

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    K14 (BRCA mutant)

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    K15 (BRCA mutant)

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    K16 (BRCA mutant)

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    K17 (BRCA mutant)

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    K18 (BRCA mutant)

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    K19 (BRCA mutant)

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    K20 (BRCA mutant)

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    K21 (BRCA mutant)

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    K22 (BRCA mutant)

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    K23 (BRCA mutant)

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    K24 (BRCA mutant)

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    K26 (BRCA mutant)

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    K27 (BRCA mutant)

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    jenntnbc4m33118

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    BRCA1-associated-9

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    BRCA1-associated-8

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    BRCA1-associated-7

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    BRCA1-associated-6

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    BRCA1-associated-5

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    BRCA1-associated-4

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    BRCA1-associated-3

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    BRCA1-associated-2

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    BRCA1-associated-10

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    BRCA1-associated-1

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    BRCA WT vs BRCA1 associated TNBC

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    BRCA-WT-6

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    BRCA-WT-5

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    BRCA-WT-4

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    BRCA-WT-3

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    BRCA-WT-2

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    BRCA-WT-1

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    Liu et al, 2019 - PP

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    Liu et al, 2019 - PO

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    Liu et al, 2019 - PM

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    Liu et al, 2019 - PL

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    Liu et al, 2019 - PK

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    Liu et al, 2019 - PJ

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    Liu et al, 2019 - PH

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    Liu et al, 2019 - PG

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    Liu et al, 2019 - PF

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    Liu et al, 2019 - PE

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    Liu et al, 2019 - PC

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    Liu et al, 2019 - PB

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    Liu et al, 2019 - PA

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    Liu et al, 2019 - P9

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    Liu et al, 2019 - P8

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    Liu et al, 2019 - P7

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    Liu et al, 2019 - P6

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    Liu et al, 2019 - P5

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    Liu et al, 2019 - P4

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    Liu et al, 2019 - P2

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    Liu et al, 2019 - P1

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    Liu et al, 2019 - N3

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    Liu et al, 2019 - N2

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    Liu et al, 2019 - N1

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    Liu et al, 2019 - AV1

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    Liu et al, 2019 - AS4

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    Liu et al, 2019 - AS3

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    Liu et al, 2019 - AS2

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    Liu et al, 2019 - AS1

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    Liu et al, 2019 - AL4

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    Liu et al, 2019 - AL3

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    Liu et al, 2019 - AL2

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    Liu et al, 2019 - AL1

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    Orion CRC18 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC17 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC16 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC15 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC14 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC13 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC12 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC11 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC10 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC09 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC07 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC06 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC05 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC04 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC03 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC02 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC01 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC40 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC39 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC38 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC37 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC36 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC35 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC34 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC33_02 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC33_01 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC32 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC31 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC30 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC29 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC28 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC27 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC26 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC25 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC24 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC23 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC22 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC21 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC08 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC20 - overview - Lin, Chen, Campton et al., 2023

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    Orion CRC19 - overview - Lin, Chen, Campton et al., 2023

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    CRC18 - H&E - overview - Lin, Wang, Coy et al., 2021

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    CRC17 - overview - Lin, Wang, Coy et al., 2021

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    CRC17 - H&E - overview - Lin, Wang, Coy et al., 2021

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    CRC16 - overview - Lin, Wang, Coy et al., 2021

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    CRC16 - H&E - overview - Lin, Wang, Coy et al., 2021

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    CRC15 - overview - Lin, Wang, Coy et al., 2021

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    CRC15 - H&E - overview - Lin, Wang, Coy et al., 2021

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    CRC14 - overview - Lin, Wang, Coy et al., 2021

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    CRC14 - H&E - overview - Lin, Wang, Coy et al., 2021

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    CRC13 - overview - Lin, Wang, Coy et al., 2021

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    CRC13 - H&E - overview - Lin, Wang, Coy et al., 2021

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    CRC12 - overview - Lin, Wang, Coy et al., 2021

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    CRC12 - H&E - overview - Lin, Wang, Coy et al., 2021

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    CRC11 - overview - Lin, Wang, Coy et al., 2021

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    CRC11 - H&E - overview - Lin, Wang, Coy et al., 2021

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    CRC10 - overview - Lin, Wang, Coy et al., 2021

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    CRC10 - H&E - overview - Lin, Wang, Coy et al., 2021

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    CRC08 - overview - Lin, Wang, Coy et al., 2021

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    CRC09 - H&E - overview - Lin, Wang, Coy et al., 2021

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    CRC08 - overview - Lin, Wang, Coy et al., 2021

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    CRC08 - H&E - overview - Lin, Wang, Coy et al., 2021

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    CRC07 - overview - Lin, Wang, Coy et al., 2021

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    CRC07 - H&E - overview - Lin, Wang, Coy et al., 2021

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    CRC06 - overview - Lin, Wang, Coy et al., 2021

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    CRC06 - H&E - overview - Lin, Wang, Coy et al., 2021

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    CRC05 - overview - Lin, Wang, Coy et al., 2021

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    CRC05 - H&E - overview - Lin, Wang, Coy et al., 2021

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    CRC04 - overview - Lin, Wang, Coy et al., 2021

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    CRC04 - H&E - overview - Lin, Wang, Coy et al., 2021

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    CRC03 - overview - Lin, Wang, Coy et al., 2021

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    CRC03 - H&E - overview - Lin, Wang, Coy et al., 2021

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    CRC02 - overview - Lin, Wang, Coy et al., 2021

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    CRC02 - H&E - overview - Lin, Wang, Coy et al., 2021

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    CRC01 - overview - Lin, Wang, Coy et al., 2021

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    CRC01 - H&E - overview - Lin, Wang, Coy et al., 2021

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    Pathological Annotations - CRC01 - Lin, Wang, Coy et al, 2021

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    CRC01 - 25 CyCIF sections - Lin, Wang, Coy et al, 2021

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    Figure 7 and 8

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    Figure 2

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    Figure 11 and 12

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    Figure 10

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    Clinical Benefit - Cisplatin Biopsy

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    Clinical Benefit - Cis Wee1i Biopsy

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    No Clinical Benefit - Cis Wee1i Biopsy

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    No Clinical Benefit - Cisplatin Biopsy

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    Colon Adenocarcinoma - Gaglia et al, 2018 - Case 1

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    Temporal and spatial topography of cell proliferation in cancer

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    Plexiform Schwannoma (Spinal Nerve Root)

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    Plexiform Schwannoma (Soft Tissue)

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    Plexiform Schwannoma (Soft Tissue)

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    Intraneural Schwannoma (Finger)

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    Plexiform Schwannoma (Finger)

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    Plexiform Schwannoma (Larynx)

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    Plexiform Schwannoma (Larynx)

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    Schwannoma (Spinal Nerve Root)

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    Schwannoma (Spinal Nerve Root)

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    Schwannoma (Spinal Nerve Root)

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    Vestibular Schwannoma 2

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    Meningioma

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    Vestibular Schwannoma 1

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    Vestibular Schwannoma 1

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    Meningioma

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    Multimodal spatial profiling of colorectal cancer using Orion

    Story Cancer type Organism Modality Link Antibodies targets in the story
    BRCA-WT TNBC 1 Breast Human CyCIF Here CD163, CD68, Keratin, Ki67, 53BP1, CD4, CD8a, FOXP3
    BRCA-WT TNBC 2 Breast Human CyCIF Here CD163, CD68, Keratin, Ki67, 53BP1, CD4, CD8a, FOXP3
    BRCA-WT TNBC 3 Breast Human CyCIF Here CD163, CD68, Keratin, Ki67, 53BP1, CD4, CD8a, FOXP3
    BRCA-WT TNBC 4 Breast Human CyCIF Here CD163, CD68, Keratin, Ki67, 53BP1, CD4, CD8a, FOXP3
    BRCA-WT TNBC 5 Breast Human CyCIF Here CD163, CD68, Keratin, Ki67, 53BP1, CD4, CD8a, FOXP3
    BRCA-WT TNBC 6 Breast Human CyCIF Here CD163, CD68, Keratin, Ki67, 53BP1, CD4, CD8a, FOXP3
    BRCA1-associated TNBC 1 Breast Human CyCIF Here CD163, CD68, Keratin, Ki67, 53BP1, CD4, CD8a, FOXP3
    BRCA1-associated TNBC 2 Breast Human CyCIF Here CD163, CD68, Keratin, Ki67, 53BP1, CD4, CD8a, FOXP3
    BRCA1-associated TNBC 3 Breast Human CyCIF Here CD163, CD68, Keratin, Ki67, 53BP1, CD4, CD8a, FOXP3
    BRCA1-associated TNBC 4 Breast Human CyCIF Here CD163, CD68, Keratin, Ki67, 53BP1, CD4, CD8a, FOXP3
    BRCA1-associated TNBC 5 Breast Human CyCIF Here CD163, CD68, Keratin, Ki67, 53BP1, CD4, CD8a, FOXP3
    BRCA1-associated TNBC 6 Breast Human CyCIF Here CD163, CD68, Keratin, Ki67, 53BP1, CD4, CD8a, FOXP3
    BRCA1-associated TNBC 7 Breast Human CyCIF Here CD163, CD68, Keratin, Ki67, 53BP1, CD4, CD8a, FOXP3
    BRCA1-associated TNBC 8 Breast Human CyCIF Here CD163, CD68, Keratin, Ki67, 53BP1, CD4, CD8a, FOXP3
    BRCA1-associated TNBC 9 Breast Human CyCIF Here CD163, CD68, Keratin, Ki67, 53BP1, CD4, CD8a, FOXP3
    BRCA1-associated TNBC 10 Breast Human CyCIF Here CD163, CD68, Keratin, Ki67, 53BP1, CD4, CD8a, FOXP3
    Clinical Benefit - Cisplatin Biopsy Breast Human CyCIF Here pCDK1/2/3/5, pHH3, pan-cytokeratin, CD8a, CD4, CD68, CD163, CD14
    Clinical Benefit - Cis Wee1i Biopsy Breast Human CyCIF Here pCDK1/2/3/5, pHH3, pan-cytokeratin, CD8a, CD4, CD68, CD163, CD14
    No Clinical Benefit - Cisplatin Biopsy Breast Human CyCIF Here pCDK1/2/3/5, pHH3, pan-cytokeratin, CD8a, CD4, CD68, CD163, CD14
    No Clinical Benefit - Cis Wee1i Biopsy Breast Human CyCIF Here pCDK1/2/3/5, pHH3, pan-cytokeratin, CD8a, CD4, CD68, CD163, CD14
    Spatially resolved immune profiling of lung adenocarcinoma mouse model KRas/p53 mutant Lung GEMM CyCIF Here TTF1, CD45, CD11c, CD45R, FOXP3, CD4, CD8, Granzyme B, Perforin
    Tonsil Normal Human CyCIF Here CD45, IBA1, Keratin, α-SMA, CD20, CD3d, CD4, CD8a, CD14, CD163, CD11b, CD68
    Tonsil Normal Human IHC Here CD3, CD4, CD8, CD20, CD68, FOXP3, PD1, PD-L1
    Lung-1-LN: Lung adenocarcinoma metastasis to lymph node Lung Human CyCIF Here CD45, IBA1, Keratin, α-SMA, CD20, CD4, CD8a, CD163, CD11b, CD68, CD14,
    Lung-2-BR: Lung squamous cell carcinoma metastasis to brain Lung Human CyCIF Here CD45, IBA1, Keratin, α-SMA, CD20, CD4, CD8a, CD163, CD11b, CD68, CD14,
    Lung-3-PR: Primary lung squamous cell carcinoma Lung Human CyCIF Here Keratin, α-SMA, CD45, IBA1, PD-L1, CD3d, CD20, CD4, FOXP3, CD8a, PD1, LAG3, CD163, CD68, CD11b, CD14
    TOPACIO Responder Ovarian Human CyCIF    
    TOPACIO Non-responder Ovarian Human CyCIF